Mitochondrial Fission in HD
Principal Investigator: Ella Bossy-Wetzel, Ph.D.
Department: Biomolecular Science Center
Source: National Institutes of Health (NIH)/National Institute of Neurological Disorders and Stroke (NINDS)
Project Title: Mitochondrial Fission in Huntington's Disease
Total Project Funding: $1,238,024 (4 years)
Description: Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an abnormal polyglutamine expansion in the huntington protein, leading to progressive dementia, motor defects, and psychiatric abnormalities. Presently, HD remains without cure as neurons die selectively by an unknown mechanism.
Quote: Scientific breakthroughs are desperately needed to unravel how mutant htt causes neuronal demise in Huntington's disease. This grant will help us pursue treatment and possible cure of Huntington's.
