Stem Cells Cardiac Remodeling
Principal Investigator: Dinender Kumar Singla, Ph.D.
Department: Biomolecular Science Center
Source: National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI)
Project Title: Factors Released From Embryonic Stem cells and Cardiac Remodeling
Total Project Funding: $1,775,000 (5 years)
Description: These studies will define the effect of transplanted ES cells or ES-CM in an infarcted mouse heart on cardiac regeneration and remodeling and mechanisms of inhibition of apoptosis and fibrosis that may play a role in improved cardiac function.
Quote: We've found that stem cells can improve heart function after a heart attack, even though 80-90 percent of the transplanted cells die. We want to find out which factors in stem cells help or hinder heart tissue regeneration, and can they be isolated for possible new therapeutic alternatives.
